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Crohn's disease is a chronic inflammatory disorder that causes ulcerations in the small and [[LargeBowel large intestines]]. Many scientists consider Crohn's to be an [[AutoimmuneDisorders autoimmune disease]]--an illness that occurs when the body tissues are attacked by its own immune system. However, Anthony Segal (University College London, UK) and colleagues have found that, counter intuitively, the inflammation in Crohn's arises due to a weak immune response.
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The multicenter research team confirmed the involvement of one gene, called ""Nod2"" or CARD15, and discovered that a defect of the interleukin-23 receptor gene (IL-23R) also led to the development of Crohn's disease.
